The Great Humphead is located at the bottom of Tide Pool's 2nd level, The Great Lake. This lake is filled to the brim with Flying Fish. If you want to kill the Humphead, it is recommended to kill any Flying Fish that might damage the player before attempting to challenge Humphead.
Humphead is surprisingly easy to kill even if you have no loot. There are multiple strategies:
- Go near the entrance of the shipwreck, and whip him/slash him with Excalibur, as he cannot not reach the player through the entrance.
- Find a curse pot and throw it at him, which will lower him to 1 health.
- Throwing 4 Paste Bombs at him, or two with the Powerpack.
- Using a Shotgun.
It may be prudent to use the Clone Gun on him if the player has the power to kill four Humpheads (likely through a Shotgun) and has nothing else better to clone, as the Mystery Boxes may prove useful.